Changes in endogenous prostacyclin in the rat brain during clinical death and after resuscitation

• Authors: Andrzej Kapuscinski
• Languages of publication: EN

Abstracts

EN

By means of the radioimmunologic method changes of concentration of 6-keto prostaglandin F1alpha(PGF1alpha) - the stable metabolite of prostacyclin in the rat brain have been evaluated during 5-min clinical death and up to 2 hrs after resuscitation Ischemia did not produce significant changes of 6-keto-PGF1 in the and 7-fold control values. Later the concentration of 6-keto-PGF1alpha in the brain decreased reaching in 30 min a 3-fold the control level, and in 60 and 120 min after resuscitation control values. The reasons of unsuccessful therapy of ischemic stroke with prostacyclin are discussed.

Keywords

EN

ISCHAEMIA; PROSTACYCLIN; RAT BRAIN

Discipline

• NEUROSCIENCE: NEUROSCIENCE

• Publisher: Association of Polish Neuropathologists; Medical Research Centre, Polish Academy of Sciences
• Journal: Neuropatologia Polska
• Year: 1992
• Volume: 30
• Issue: 2
• Pages: 127-132

Contributors

author

Andrzej Kapuscinski

• Document Type: article
• Publication order reference: Andrzej Kapuscinski