Changes in endogenous prostacyclin in the rat brain during clinical death and after resuscitation
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By means of the radioimmunologic method changes of concentration of 6-keto prostaglandin F1alpha(PGF1alpha) - the stable metabolite of prostacyclin in the rat brain have been evaluated during 5-min clinical death and up to 2 hrs after resuscitation Ischemia did not produce significant changes of 6-keto-PGF1 in the and 7-fold control values. Later the concentration of 6-keto-PGF1alpha in the brain decreased reaching in 30 min a 3-fold the control level, and in 60 and 120 min after resuscitation control values. The reasons of unsuccessful therapy of ischemic stroke with prostacyclin are discussed.
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