EN
Several methods used to cultivate anchorage-dependent animal cells on a large scale are presented. These methods include the cultures on microcarriers in stirred and air-lift bioreactors, the cultures in hollow-fiber and flat-plate membrane bioreactors as well as the cultures attached to porous or fiber solid supports. The critical parameter in anchorage-dependent cultures is the adhesiveness of the cells to the carrier materials and the surface proliferation rate.