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2002 | 50 | 6 | 391-396
Article title

Streptomyces and Escherichia coli, model organisms for the analysis of the initiation of bacterial chromosome replication

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Languages of publication
EN
Abstracts
EN
Streptomyces coelicolor A3(2) and Escherichia coli are quite different in their life-style and the structures of their genomes. Streptomyces exhibit complex multicellular development including formation of multigenomic hyphae during growth. These organisms possess a large linear (8.7 Mb) and GC-rich (~72%) chromosome. The genome sequence of S. coelicolor has just been completed. The difference between E. coli and Streptomyces making them an excellent model organisms for a comparison of their replication modes. In this review, we compare initiation of chromosome replication in both organisms. Their replication origins are different in size, but both have DnaA boxes ? a binding motifs for initiator DnaA protein. The two DnaA proteins have practically the same biochemical properties. Many aspects of the control of initiation seem to be similar. A comparison of the two systems thus allows us to define those aspects of replication initiation that are universally used in the eubacterial kingdom.
Publisher

Year
Volume
50
Issue
6
Pages
391-396
Physical description
Contributors
References
Document Type
REVIEW
Publication order reference
W. Messer, Max-Planck-Institut fur molekulare Genetik, D-14195 Berlin, Germany
Identifiers
YADDA identifier
bwmeta1.element.element-from-psjc-09ce4f87-3155-33dc-aa11-a732c3ca7b52
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