Streptomyces and Escherichia coli, model organisms for the analysis of the initiation of bacterial chromosome replication

• Authors: W. Messer , J. Zakrzewska-Czerwinska
• Languages of publication: EN

Abstracts

EN

Streptomyces coelicolor A3(2) and Escherichia coli are quite different in their life-style and the structures of their genomes. Streptomyces exhibit complex multicellular development including formation of multigenomic hyphae during growth. These organisms possess a large linear (8.7 Mb) and GC-rich (~72%) chromosome. The genome sequence of S. coelicolor has just been completed. The difference between E. coli and Streptomyces making them an excellent model organisms for a comparison of their replication modes. In this review, we compare initiation of chromosome replication in both organisms. Their replication origins are different in size, but both have DnaA boxes ? a binding motifs for initiator DnaA protein. The two DnaA proteins have practically the same biochemical properties. Many aspects of the control of initiation seem to be similar. A comparison of the two systems thus allows us to define those aspects of replication initiation that are universally used in the eubacterial kingdom.

Keywords

EN

DNAA; ESCHERICHIA COLI; STREPTOMYCES COELICOLOR

Discipline

• EXPERIMENTAL_BIOLOGY_&_MEDICINE: EXPERIMENTAL BIOLOGY & MEDICINE

• Publisher: Ludwik Hirszfeld Institute of Immunology and Experimental Therapy, Polish Academy of Sciences
• Journal: Archivum Immunologiae et Therapiae Experimentalis
• Year: 2002
• Volume: 50
• Issue: 6
• Pages: 391-396

Contributors

author

W. Messer

author

J. Zakrzewska-Czerwinska

• Document Type: REVIEW
• Publication order reference: W. Messer, Max-Planck-Institut fur molekulare Genetik, D-14195 Berlin, Germany