PL EN


Preferences help
enabled [disable] Abstract
Number of results
2008 | 49 | 2 | 193-199
Article title

Cancer stem cells: the theory and perspectives in cancer therapy

Title variants
Languages of publication
EN
Abstracts
EN
The cancer stem cell theory elucidates not only the issue of tumour initiation and development, tumour's ability to metastasise and reoccur, but also the ineffectiveness of conventional cancer therapy. This review examines stem cell properties, such as self-renewal, heterogeneity, and resistance to apoptosis. The ?niche' hypothesis is presented, and mechanisms of division, differentiation, self-renewal and signalling pathway regulation are explained. Epigenetic alterations and mutations of genes responsible for signal transmission may promote the formation of cancer stem cells. We also present the history of development of the cancer stem cell theory and discuss the experiments that led to the discovery and confirmation of the existence of cancer stem cells. Potential clinical applications are also considered, including therapeutic models aimed at selective elimination of cancer stem cells or induction of their proper differentiation.
Keywords
EN
Discipline
Publisher

Year
Volume
49
Issue
2
Pages
193-199
Physical description
Contributors
author
author
author
author
References
Document Type
ARTICLE
Publication order reference
Justyna Gil, Department of Genetics, Medical University of Wroclaw, Marcinkowskiego 1, 50?368 Wroc?aw, Poland
Identifiers
YADDA identifier
bwmeta1.element.element-from-psjc-09b0cbe4-72d9-3b12-b531-86f4d4c511e7
JavaScript is turned off in your web browser. Turn it on to take full advantage of this site, then refresh the page.