Controversies about iron in parkinsonian and control substantia nigra

• Authors: J. Galazka-Friedman , A. Friedman
• Languages of publication: EN

Abstracts

EN

According to the oxidative stress theory iron may play an important role in the pathogenesis of neurodegenerative diseases, as e.g. Parkinson's disease (PD). This review presents the results of studies, obtained by various methods, of iron in substantia nigra (SN) - a cerebral structure which degenerates in PD - and shows controversies concerning the amount of iron, its redox state, and the iron binding compounds. Taking into account all published experimental results, the increase in the concentration of iron in parkinsonian SN vs. control may be estimated as (3 + - 5)%. The presence of large amounts of divalent iron in post mortem SN can be unequivocally negated. It is, however, still possible that iron is involved in the pathogenesis of PD, as even minor changes in the amount and form of iron may initiate processes leading to cells death.

Keywords

EN

IRON; PARKINSON'S DISEASE; SUBSTANTIA NIGRA

Discipline

• EXPERIMENTAL_BIOLOGY_&_MEDICINE: EXPERIMENTAL BIOLOGY & MEDICINE

• Publisher: Marceli Nencki Institute of Experimental Biology, Polish Academy of Sciences
• Journal: Acta Neurobiologiae Experimentalis
• Year: 1997
• Volume: 57
• Issue: 3
• Pages: 217-225

Contributors

author

J. Galazka-Friedman

author

A. Friedman

• Document Type: article
• Publication order reference: A. Friedman, Department of Neurology, Warsaw Medical Academy, 1a Banach St., 02-097 Warsaw, Poland, Email: [e-mail]