Neuropeptide Y (NPY) and its mRNA in discrete brain areas after subchronic administration of neuroleptics

• Authors: Z.S. Herman
• Languages of publication: EN

Abstracts

EN

Classical (chlorpromazine, haloperidol) and atypical (sulpiride and clozapine) neuroleptics applied for a period of 2 weeks diminished neuropeptide Y (NPY) levels in nucleus accumbens, but not in striatum. These changes were correlated with NPY mRNA level. However, the effect of these neuroleptics on the level of NPY in hypothalamus was different. It is suggested that changes in NPY levels caused by neuroleptics are mediated by dopaminergic D1/D2 receptors.

Keywords

EN

HYPOTHALAMUS; NEUROLEPTICS; NEUROPEPTIDE Y; NUCLEUS ACCUMBENS; RAT; STRIATUM

Discipline

• EXPERIMENTAL_BIOLOGY_&_MEDICINE: EXPERIMENTAL BIOLOGY & MEDICINE

• Journal: Acta Neurobiologiae Experimentalis
• Year: 1996
• Volume: 56
• Issue: 1
• Pages: 55-61

Contributors

author

Z.S. Herman

• Document Type: proceeding
• Publication order reference: Z.S.Herman