Negative signals from FceRI engagement attenuate mast-cell functions

• Authors: R. Molfetta , G. Peruzzi , A. Santoni , R. Paolini
• Languages of publication: EN

Abstracts

EN

Mast cells have long been recognized as the critical tissue-based effector cells in IgE-mediated allergic diseases. Ligation of the high-affinity receptor for IgE (FceRI), constitutively expressed on mast cells, promotes cell activation and immediate release and production of pro-inflammatory mediators. Besides these positive signals, FceRI aggregation has recently been understood to generate negative intracellular signals capable of limiting mast-cell functional responses. This review is aimed at providing a summary of the mechanisms through which FceRI engagement can generate negative signals and regulate mast-cell function. Similar mechanisms are employed by other receptors expressed by immune cells, such as T cell and B cell receptors, pointing to a general concept in negative immunoreceptor signaling.

Keywords

EN

MAST CELL; SIGNAL TRANSDUCTION

Discipline

• IMMUNOLOGY: IMMUNOLOGY

• Publisher: Ludwik Hirszfeld Institute of Immunology and Experimental Therapy, Polish Academy of Sciences
• Journal: Archivum Immunologiae et Therapiae Experimentalis
• Year: 2007
• Volume: 55
• Issue: 4
• Pages: 219-229

Contributors

author

R. Molfetta

author

G. Peruzzi

author

A. Santoni

author

R. Paolini

• Document Type: REVIEW
• Publication order reference: Rossella Paolini, Department of Experimental Medicine, University 'La Sapienza', Viale Regina Elena 324, 00161 Rome, Italy