Full-text resources of PSJD and other databases are now available in the new Library of Science.
Visit https://bibliotekanauki.pl

PL EN


Preferences help
enabled [disable] Abstract
Number of results
2002 | 50 | 2 | 95-104

Article title

Low molecular weight protein tyrosine phosphatase and human disease: in search of biochemical mechanisms

Title variants

Languages of publication

EN

Abstracts

EN
A major challenge in the post-genomic era is to identify the physiological function of genes and elucidate the molecular basis for human disease. Genetic polymorphisms offer a convenient aveune for these efforts by providing evidence for the involvement of a given gene in human pathophysiology. Here we review the current evidence linking the low molecular weight protein tyrosine phosphatase (LMPTP) to several common diseases, including allergy, asthma, obesity, myocardial hypertrophy, and Alzheimer's disease. Based on the know effects of the genetic polymorphisms on the alternative mRNA splicing and enzyme levels of LMPTP, we discuss the possible molecular mechanisms of LMPTP involvement in these diseases.

Contributors

author
author
author

References

Document Type

REVIEW

Publication order reference

N. Bottini, Program of Signal Transduction, La Jolla Cancer Research Center, The Burnham Institute, 10901 North Torrey Pines Road, La Jolla, CA 92037, USA,

Identifiers

YADDA identifier

bwmeta1.element.element-from-psjc-04b72e6d-6312-3494-b693-251c23772fe0
JavaScript is turned off in your web browser. Turn it on to take full advantage of this site, then refresh the page.