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1994 | 48 | 5 | 631-644
Article title

Inductors and age effects on microsomal electron transfer chain from rat liver

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Languages of publication
PL
Abstracts
EN
In this paper we showed age effect on NADPH-cytochrome P-450 reductase activity, cytochrome b5 and NADH-cytochrome b reductase from rat liver.We discussed effect of some I, II, and III classes inductor also.Activity NADPH-cytochrom P-450 reductase softly decreased from 0.5-2-month of life, but in older groups gradually increased.In 28-month-old rats it was twice fold youngest.Phenobarbital and dexamethasone (without 28-month-old age rats) induced but ?-naphthoflavone inhibited activity of this reductase.Cytochrome b content softly decreased to 4-month of life.In older animals changed of this hemoprotein content were not observed.The examined inductors of monooxygenase system decreased cytochrome b level.NADH-cytochrome b5 reductase activity increased to 1-month of life, but in older group decreased.After 2-month changes of activity were very small only.Phenobarbital, ?-naphthoflavone and dexamothasone inhibited activity of this reductase.
Keywords
EN
Year
Volume
48
Issue
5
Pages
631-644
Physical description
References
Document Type
article
Publication order reference
A.Plewka
YADDA identifier
bwmeta1.element.element-from-psjc-047d33e2-3c44-3de7-ae69-235510ae4ffc
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