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Journal
1998 | 3 | 35-51
Article title

Prions - the new infectious agent

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Languages of publication
PL
Abstracts
EN
Prions are devoid of nucleic acids and they are composed mainly or exclusively of protein PrPSC, that is a conformational variant of the normal cellular prion protein PrPC, encoded by a chromosomal gene. Conversion of PrPC into PrPSC is a posttranslational process which is accompanied by the acquisition of high b-sheet content. Human prion diseases may be of sporadic, genetic or infectious origin. Human activity caused a 'mad cow disease' epidemic, iatrogenic Creutzfeldt-Jakob disease (CJD), and lately, a new variant of CJD, which is thought to be a result of transmission of bovine prions to humans. Prion diseases are always fatal, and there is a need to develop effective methods of prevention and therapy for these disorders.
Publisher

Journal
Year
Issue
3
Pages
35-51
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Contributors
author
References
Document Type
article
Publication order reference
T. Gogiel, Zaklad Biochemii Akademia Medyczna, ul. Mickiewicza 2, 15-230 Bialystok-8, Poland
Identifiers
YADDA identifier
bwmeta1.element.element-from-psjc-046eab62-878a-3a05-8109-d943af5ab33b
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