Aneuploidy, chromosomal missegregation, and cell cycle reentry in Alzheimer's disease

• Authors: C. Zekanowski , U. Wojda
• Languages of publication: EN

Abstracts

EN

Alzheimer's disease (AD) is a neurodegenerative disorder with a complex etiology and pathogenesis. Chromosome missegregation was proposed two decades ago to be responsible for neurodegeneration in AD patients. It was speculated that the aneuploidy is a result of aberrant cell cycle of neuronal progenitors during adult neurogenesis and/or of mature neurons. There is mounting evidence of increased rate of general aneuploidy and cell cycle reentry in the AD patients' brains, with area-specific pattern. In this review, we discuss the involvement of chromosome instability, genome damage and cell cycle impairment in AD pathology.

Keywords

EN

ALZHEIMER'S DISEASE; ANEUPLOIDY; APOPTOSIS; CELL CYCLE; CHROMOSOME MISSEGREGATION; DNA DAMAGE; DNA REPAIR; DOWN'S SYNDROME; NEURON; OXIDATIVE STRESS

Discipline

• EXPERIMENTAL_BIOLOGY_&_MEDICINE: EXPERIMENTAL BIOLOGY & MEDICINE

• Publisher: Marceli Nencki Institute of Experimental Biology, Polish Academy of Sciences
• Journal: Acta Neurobiologiae Experimentalis
• Year: 2009
• Volume: 69
• Issue: 2
• Pages: 232-253

Contributors

author

C. Zekanowski

author

U. Wojda

• Document Type: ARTICLE
• Publication order reference: Cezary Zekanowski, Department of Neurodegenerative Disorders, Mossakowski Medical Research Centre, Polish Academy of Sciences, Warsaw, Poland