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2009 | 69 | 2 | 232-253
Article title

Aneuploidy, chromosomal missegregation, and cell cycle reentry in Alzheimer's disease

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Abstracts
EN
Alzheimer's disease (AD) is a neurodegenerative disorder with a complex etiology and pathogenesis. Chromosome missegregation was proposed two decades ago to be responsible for neurodegeneration in AD patients. It was speculated that the aneuploidy is a result of aberrant cell cycle of neuronal progenitors during adult neurogenesis and/or of mature neurons. There is mounting evidence of increased rate of general aneuploidy and cell cycle reentry in the AD patients' brains, with area-specific pattern. In this review, we discuss the involvement of chromosome instability, genome damage and cell cycle impairment in AD pathology.
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69
Issue
2
Pages
232-253
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ARTICLE
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Cezary Zekanowski, Department of Neurodegenerative Disorders, Mossakowski Medical Research Centre, Polish Academy of Sciences, Warsaw, Poland
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bwmeta1.element.element-from-psjc-0325d12c-d3c3-3ee7-aa0f-c77b667aa76f
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