Effect of acute and chronic lead exposure on the level of sulphydryl groups in rat brain

• Authors: B. Dabrowska-Bouta , L. Struzynska , U. Rafalowska
• Languages of publication: EN

Abstracts

EN

Lead is known to be a potent neurotoxic agent. The interactions of lead with proteins are considered to be at least one of the mechanisms due to which lead exerts its toxicity. In the present work we demonstrate that acute and chronic models of exposure to lead affected the level of total and protein-bound SH groups in homogenates and synaptosomes obtainded from rat brains. The concentrations of SH groups were lowered significantly (P less then 0.05) in both types of poisoning. Different classes of cellural proteins were considered to play a role in high affinity binding of lead to these ligands.

Keywords

EN

LEAD

Discipline

• EXPERIMENTAL_BIOLOGY_&_MEDICINE: EXPERIMENTAL BIOLOGY & MEDICINE

• Publisher: Marceli Nencki Institute of Experimental Biology, Polish Academy of Sciences
• Journal: Acta Neurobiologiae Experimentalis
• Year: 1996
• Volume: 56
• Issue: 1
• Pages: 233-236

Contributors

author

B. Dabrowska-Bouta

author

L. Struzynska

author

U. Rafalowska

• Document Type: proceeding
• Publication order reference: B.Dabrowska-Bouta