Human mitochondria in health, disease, ageing and cancer

• Authors: E. Bartnik , A. Lorenc , K. Mroczek
• Languages of publication: EN

Abstracts

EN

In every human cell there are hundreds of mitochondria, which are required for oxidative phosphorylation as well as many other metabolic processes. Each mitochondrion contains approximately 5 mitochondrial DNA molecules. These circular DNAs of 16.5 kb in size contain only 39 genes . Mutations in mitochondrial DNA are responsible for many diseases. Alterations in these molecules may also play a role in ageing and in tumour formation.

Keywords

EN

AGEING; HUMAN CELL; MITOCHONDRIA; MUTATION

Discipline

• GENETICS: GENETICS

• Publisher: Institute of Plant Genetics, Polish Academy of Sciences
• Journal: Journal of Applied Genetics
• Year: 2001
• Volume: 42
• Issue: 1
• Pages: 65-71

Contributors

author

E. Bartnik

author

A. Lorenc

author

K. Mroczek

• Document Type: REVIEW
• Publication order reference: E. Bartnik, Institute of Biochemistry and Biophysics, Polish Academy of Sciences, ul. Pawinskiego 5a, 02-106 Warszawa, Poland, e-mail: [e-mail]