A role of protein kinase C isoforms in tumorigenicity and apoptotic cells death
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Protein kinase C comprises a family of at least 13 distinct serine/threonine kinase isoenzymes that have important action in transmembrane signal transduction pathways and have been reported to regulate cell proliferation, differentiation, cell-to-cell interaction, cytoskeletal functions, gene transcription, apoptosis and drug resistance. The results of investigations show differential redistribution isozymes in each organs and their specyfic activity in determined diseases.
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M. Rybczynska, Zaklad Chemii Klinicznej AM, ul. Przybyszewskiego 49, 60-355 Poznan, Poland