The role and the function of voltage-gated chloride channels of the ClC family and its defects leading to genetic diseases

• Authors: K. Dolowy , P. Bednarczyk , R. Hordejuk , B. Dworakowska , E. Nurowska , W. Jarzabek
• Languages of publication: PL

Abstracts

EN

There are 9 channels of the ClC family in mammals and few others in fishes, plants, yeast and bacteria. The ClC channels are present in different tissues and play a role in transmembrane potential stabilization, transepithelial transport, cell volume regulation, acidification of intracellular organelles. The genetic defects of ClC-1 chloride channel lead to myotonias, the defect inClC-5 channel to the formation of stones in kidney, while the defect in ClC-Kb channel leads to the Bartter?s syndrome

Keywords

EN

CHLORIDE CHANNEL; DEFECT; GENETIC DISEASE

Discipline

• EXPERIMENTAL_BIOLOGY_&_MEDICINE: EXPERIMENTAL BIOLOGY & MEDICINE

• Journal: Postępy Higieny i Medycyny Doświadczalnej
• Year: 2002
• Volume: 56
• Issue: 3
• Pages: 307-313

Contributors

author

K. Dolowy

author

P. Bednarczyk

author

R. Hordejuk

author

B. Dworakowska

author

E. Nurowska

author

W. Jarzabek

• Document Type: ARTICLE
• Publication order reference: K. Dolowy, Zak?ad Biofizyki SGGW, ul. Rakowiecka 26/30, 02-528 Warszawa, Poland