Development of tablets containing solid dispersion of ibuprofen manufactured by Hot Melt Impregnation process.

• Authors: Kamil Garbera , Katarzyna Woś-Latosi , Wiesław Sawicki
• Languages of publication: EN

Abstracts

EN

The main assumption of given study was to develop tablets containing amorphous ibuprofen by hot melt extrusion process. However proposed manufacturing procedure demonstrates quite a few differences in comparison to a conventional hot melt extrusion. Accurately the given manufacturing procedure has been called a hot melt impregnation due to the process characteristics. As a product of described process a fine free flowing extrudate is obtained. Four different compositions have been proposed. Materials prepared by hot melt impregnation technique have been extensively examined in terms of physicochemical properties and then were subjected to tablet compression process. Obtained tablets were examined in terms of thermodynamic stability and compared to marketed product containing ibuprofen.

Keywords

EN

Ibuprofen; solid dispersion; hot melt extrusion; hot melt impregnation; amorphisation; solubility enhancement

• Journal: Acta Poloniae Pharmaceutica - Drug Research
• Year: 2019
• Volume: 76
• Issue: 2
• Pages: 341-354

Dates

published

2019-04-30

Contributors

author

Kamil Garbera

author

Katarzyna Woś-Latosi

author

Wiesław Sawicki

Identifiers

DOI

10.32383/appdr/98979