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2019 | 76 | 2 | 341-354
Article title

Development of tablets containing solid dispersion of ibuprofen manufactured by Hot Melt Impregnation process.

Content
Title variants
Languages of publication
EN
Abstracts
EN
The main assumption of given study was to develop tablets containing amorphous ibuprofen by hot melt extrusion process. However proposed manufacturing procedure demonstrates quite a few differences in comparison to a conventional hot melt extrusion. Accurately the given manufacturing procedure has been called a hot melt impregnation due to the process characteristics. As a product of described process a fine free flowing extrudate is obtained. Four different compositions have been proposed. Materials prepared by hot melt impregnation technique have been extensively examined in terms of physicochemical properties and then were subjected to tablet compression process. Obtained tablets were examined in terms of thermodynamic stability and compared to marketed product containing ibuprofen.
Year
Volume
76
Issue
2
Pages
341-354
Physical description
Dates
published
2019-04-30
Contributors
References
Document Type
Publication order reference
Identifiers
YADDA identifier
bwmeta1.element.doi-10_32383_appdr_98979
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