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2019 | 76 | 2 | 225-232

Article title

TEMPERATURE DEPENDENT SOLUBILITY STUDIES OF BRIGATINIB IN SOME PURE SOLVENTS USEFUL IN DOSAGE FORM DEVELOPMENT

Content

Title variants

Languages of publication

EN

Abstracts

EN
In the current study, thermodynamic dissolution of brigatinib in six pure solvents namely, water, ethanol, isopropyl myristate (IPM), poly(ethylene glycol)-400 (PEG-400), dichloromethane (DCM) and ethyl acetate (EA) at (298.2-323.2K) temperature and 0.1 MPa atm. pressure were carried out using flask shaking technique.The mole-fraction solubility of brigatinib was obtainedgreatest in IPM (6.09 x 10-2) and least in water (3.12 x 10-6) at298.2 K.Experimentally obtained solubilities values of brigatinib were regressed using adapted Apelblat equation with root mean square deviations in the range of 1.91 to 4.67 in all solvents and similar trends were observed with increased the temperature. The solubility data generated in this investigation could be helpful for investigator for analysis/dosage form development of brigatinib.

Year

Volume

76

Issue

2

Pages

225-232

Physical description

Dates

published
2019-04-30

References

Document Type

Publication order reference

Identifiers

YADDA identifier

bwmeta1.element.doi-10_32383_appdr_94616
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