TEMPERATURE DEPENDENT SOLUBILITY STUDIES OF BRIGATINIB IN SOME PURE SOLVENTS USEFUL IN DOSAGE FORM DEVELOPMENT

• Authors: MUQTADER MOHAMMAD , Md Khalid ANWER , FARHAT FATIMA , SAAD M. ALSHAHRANI , ABDULLAH S. ALSHETAILI , AHMED ALALAIWE , BADER B. ALSULAYS , FAIYAZ SHAKEEL
• Languages of publication: EN

Abstracts

EN

In the current study, thermodynamic dissolution of brigatinib in six pure solvents namely, water, ethanol, isopropyl myristate (IPM), poly(ethylene glycol)-400 (PEG-400), dichloromethane (DCM) and ethyl acetate (EA) at (298.2-323.2K) temperature and 0.1 MPa atm. pressure were carried out using flask shaking technique.The mole-fraction solubility of brigatinib was obtainedgreatest in IPM (6.09 x 10-2) and least in water (3.12 x 10-6) at298.2 K.Experimentally obtained solubilities values of brigatinib were regressed using adapted Apelblat equation with root mean square deviations in the range of 1.91 to 4.67 in all solvents and similar trends were observed with increased the temperature. The solubility data generated in this investigation could be helpful for investigator for analysis/dosage form development of brigatinib.

Keywords

EN

Lung cancer; curve fitting; Thermodynamic dissolution; mole fraction solubility; Apelblat model

• Journal: Acta Poloniae Pharmaceutica - Drug Research
• Year: 2019
• Volume: 76
• Issue: 2
• Pages: 225-232

Dates

published

2019-04-30

Contributors

author

MUQTADER MOHAMMAD

author

Md Khalid ANWER

author

FARHAT FATIMA

author

SAAD M. ALSHAHRANI

author

ABDULLAH S. ALSHETAILI

author

AHMED ALALAIWE

author

BADER B. ALSULAYS

author

FAIYAZ SHAKEEL

Identifiers

DOI

10.32383/appdr/94616