PL EN


Preferences help
enabled [disable] Abstract
Number of results
2019 | 76 | 1 | 147-157
Article title

THE EFFECTS OF SULFUR-CONTAINING COMPOUNDS ON REDOX STATUS IN HOMOCYSTEINE-TREATED RATS

Content
Title variants
Languages of publication
EN
Abstracts
EN
There is growing interest in the activity of sulfur-containing compounds on redox balance in physiological and pathological conditions, considering that some of these compounds have not only antioxidative but also pro-oxidative activities. Aim of this study was to assess possible differences in the effects of various sulfur-containing compounds on redox balance of cardiovascular system in its physiological state and in the early onset of hyperhomocysteinemia. This experimental study divided Wistar albino rats into two groups: saline-treated (control) and DL-homocysteine-treated (experimental group). Rats from experimental group were subjected to subchronic subcutaneous administration of DL-homocysteine at dose of 0.45 ╬╝mol/g body weight twice a day for 2 weeks. At the end of this period, rats were sacrificed, and blood samples were collected to be analysed for homocysteine concentration and systemic oxidative stress. Isolated rat hearts were excised and attached to the Langendorff apparatus. To assess the effects of acute administration of L-methionine, L-cysteine, N-acetylcysteine, and sodium hydrogen sulfide, the hearts were perfused individually with each of the mentioned substances at same single dose of 0.5 mmol/l for 5 min. In collected samples of coronary venous effluent oxidative stress biomarkers were determined using spectrophotometry. Total homocysteine level was significantly higher in the experimental group than in the control group, and the effects of applied sulfur-containing compounds were significantly different in experimental and control groups. DL-homocysteine induced considerable changes in functioning of cardiovascular system even before an increase in plasma homocysteine values, and action of sulfur-containing compounds varied depending on the presence of homocysteine.
Year
Volume
76
Issue
1
Pages
147-157
Physical description
Dates
published
2019-02-28
References
Document Type
Publication order reference
Identifiers
YADDA identifier
bwmeta1.element.doi-10_32383_appdr_94079
JavaScript is turned off in your web browser. Turn it on to take full advantage of this site, then refresh the page.