POPULATION PHARMACOKINETICS OF 25-HYDROXY VITAMIN D IN NON-ELDERLY POSTMENOPAUSAL WOMEN

• Authors: JELENA DJOKOVIC , Aleksandra Tomic Lucic , OLIVERA MILOVANOVIC , DANIJELA BAZIC , MIRJANA VESELINOVIC , ALEKSANDAR DJUKIC , SANDRA MATOVIC , RADICA ZIVKOVIC ZARIC , RADMILA VELICKOVIC RADOVANOVIC , SLOBODAN JANKOVIC , JASMINA MILOVANOVIC
• Languages of publication: EN

Abstracts

EN

Introduction/aim: The aims of this study were to develop a population pharmacokinetic (PPK) model for the clearance of 25-hydroxy vitamin D in non-elderly postmenopausal women and to identify the factors which have a significant influence on its clearance. Methods: The study population consisted of postmenopausal women who had been referred for evaluation of bone mineral density (BMD) by DEXA (dual-energy x-ray absorptiometry) scanner. The population pharmacokinetics modelling was conducted using the ADVAN 1 subroutine from a non-linear mixed effects (NONMEM) program, and thirty-two covariates were assessed. Results: A total of 75 serum concentrations were obtained from the same number of postmenopausal women and used for PPK analysis. The mean values of the participants’ age was 57.92±3.93 years and their body weight was 69.76±11.49kg. A wide range of 25-hydroxy vitamin D concentrations was observed (from 3.41 to 61.92ng/mL) with a mean value of 26.19±10.95ng/mL. A total of 32 covariates were examined and preliminary results suggested the influence of six covariates on 25-hydroxy vitamin D clearance. In the final PPK model however, only one covariate was shown to have a significant impact on the clearance value – the mean daily dietary intake dose of vitamin D (DD). Conclusions: These findings offer a preliminary basis on which to determine the level of vitamin D supplementation required by individual postmenopausal women. It could prove particularly important in achieving optimal serum levels of vitamin D in this vulnerable population.

Keywords

EN

women; postmenopausal women; 25-hydroxy vitamin D; Population pharmacokinetics; NONMEM

• Journal: Acta Poloniae Pharmaceutica - Drug Research
• Year: 2019
• Volume: 76
• Issue: 1
• Pages: 129-136

Dates

published

2019-02-28

Contributors

author

JELENA DJOKOVIC

author

Aleksandra Tomic Lucic

author

OLIVERA MILOVANOVIC

author

DANIJELA BAZIC

author

MIRJANA VESELINOVIC

author

ALEKSANDAR DJUKIC

author

SANDRA MATOVIC

author

RADICA ZIVKOVIC ZARIC

author

RADMILA VELICKOVIC RADOVANOVIC

author

SLOBODAN JANKOVIC

author

JASMINA MILOVANOVIC

Identifiers

DOI

10.32383/appdr/93982