PL EN


Preferences help
enabled [disable] Abstract
Number of results
2019 | 76 | 1 | 19-27
Article title

DETERMINATION OF FLUCONAZOLE AND ITS OXIDATION PRODUCTS WITH KINETIC EVALUATION UNDER POTASSIUM PERMANGANATE TREATMENT IN ACIDIC SOLUTIONS BY ULTRA PERFORMANCE LIQUID CHROMATOGRAPHY-TANDEM MASS SPECTROMETRY

Content
Title variants
Languages of publication
EN
Abstracts
EN
For the determination of fluconazole (FLU) oxidation stability under permanganate treatment at the acidic pH, a sensitive, reproducible, and stability-indicating ultra-performance liquid chromatography–mass spectrometry (UPLC/MS) method was developed. Three additional products (tR = 5.79, 6.98, 7.54) were observed besides the FLU (tR = 6.22). The proposed method was used to study the kinetics of FLU oxidative degradation. An oxidation process followed kinetics of the second-order reaction. The degradation rate constant and the corresponding half-life obtained for the FLU oxidative degradation were 0.5626 h-1 and 16.69 h, respectively. The putative oxidation products were characterized and their fragmentation pathways, on a basis of MS/MS data, were proposed.
Year
Volume
76
Issue
1
Pages
19-27
Physical description
Dates
published
2019-02-28
Contributors
References
Document Type
Publication order reference
Identifiers
YADDA identifier
bwmeta1.element.doi-10_32383_appdr_93513
JavaScript is turned off in your web browser. Turn it on to take full advantage of this site, then refresh the page.