Immunotoxins, an Advance tool for Cancer Treatment: Review and update

• Authors: Iqra Munir , Rana D. Naseer , Mohammad Saleem , Asif Mahmood , Aisha Sultana
• Languages of publication: EN

Abstracts

EN

Conventional therapeutic approaches like chemotherapy, surgery and radiation for cancer and other malignancies have limited success rate. Several factors such as drug resistance, non-penetrability into solid tumors and unwanted toxicity due to non-specific action contribute to treatment failure. To overcome these issues, immunotoxins were developed having a target specific action. Immunotoxins are chimeric cytotoxic proteins which are formed by linking a toxin moiety to intact antibody or its fragment. Bacterial and plant based toxins are used in immunotoxins construction but they have many drawbacks in terms of immunogenicity and non-specific toxicity. Recently, a novel class of immunotoxins of human origin has been introduced. Immunotoxins fight back cancers by targeting the neoplastic cells and cause cells death by inhibiting protein synthesis. They have been categorized into two main classes, chemically conjugated immunotoxins and recombinant immunotoxins. This review summarizes recent advances in immunotoxins development and present a comprehensive illustration of sources and generations of immunotoxins. Moreover, it also highlights future directions to be explored. This review also focuses the limitations in immunotoxins development and its use.

Keywords

EN

lymphoma; malignancy; immunogenicity

• Journal: Acta Poloniae Pharmaceutica - Drug Research
• Year: 2018
• Volume: 75
• Issue: 6
• Pages: 1267-1277

Dates

published

2018-12-31

Contributors

author

Iqra Munir

author

Rana D. Naseer

author

Mohammad Saleem

author

Asif Mahmood

author

Aisha Sultana

Identifiers

DOI

10.32383/appdr/91919