FACTORS ASSOCIATED WITH ESTIMATE OF HIGH TERATOGENIC RISK IN FEMALES EXPOSED TO ANTI-INFECTIVE AND ANTI-INFLAMMATORY DRUGS DURING PREGNANCY

Grubor, Iva; Nikolić, Ljiljana; Ružić Zečević, Dejana; Milovanović, Dragan; Folić, Marko; Rosić, Nikola; Radonjić, Vesela; Janković, Slobodan M.

doi:10.32383/appdr/90828

Journal

Acta Poloniae Pharmaceutica - Drug Research

2018 | 75 | 6 | 1439-1445

Article title

FACTORS ASSOCIATED WITH ESTIMATE OF HIGH TERATOGENIC RISK IN FEMALES EXPOSED TO ANTI-INFECTIVE AND ANTI-INFLAMMATORY DRUGS DURING PREGNANCY

Authors

Iva Grubor , Ljiljana Nikolić , Dejana Ružić Zečević , Dragan Milovanović , Marko Folić , Nikola Rosić , Vesela Radonjić , Slobodan M. Janković

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Abstracts

ABSTRACT Introduction. Considering that small number of drugs are completely safe for use during pregnancy, right choice and adequate risk assessment is extremely important. Objective. The aim of this study was to analyze factors associated with estimate of high teratogenic risk (as judged by clinical pharmacologist) in pregnant females who were prescribed anti-infective drugs or mild analgesics. Methods. A cross-sectional study included 284 pregnant women who came for an advice about teratogenic risk to clinical pharmacologist in Clinical Centre Kragujevac, Serbia during the period from 1997 to 2012. All of included pregnant women were prescribed mild analgesics and/or anti-infective drugs during the first 3 months of pregnancy. The data were collected from patient files and by phone interviews. Results. Clinical pharmacologists estimated the risk of teratogenicity as “high” in pregnant females who were using tetracyclines or propionic acid derivatives. Disorders of development reported by mothers during phone interviews were associated with cephalosporin use during first 3 months of pregnancy, while miscarriages or abortions happened more often in women who used a tetracycline. Conclusions. Estimate of risk from congenital anomalies after use of drugs during pregnancy, which make clinical pharmacologists as part of their routine healthcare services, depends on amount of published data about previous experiences with specific drugs during the first 3 months of pregnancy. Key Words: pregnancy; drugs; risk of teratogenicity; risk estimate

Keywords

pregnancy drugs risk of teratogenicity risk estimate

Journal

Acta Poloniae Pharmaceutica - Drug Research

Year

2018

Volume

Issue

Pages

1439-1445

Physical description

Dates

published

2018-12-31

Contributors

author

Iva Grubor

author

Ljiljana Nikolić

author

Dejana Ružić Zečević

author

Dragan Milovanović

author

Marko Folić

author

Nikola Rosić

author

Vesela Radonjić

author

Slobodan M. Janković

References

Document Type

Publication order reference

Identifiers

DOI

10.32383/appdr/90828

YADDA identifier

bwmeta1.element.doi-10_32383_appdr_90828