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2018 | 75 | 6 | 1369-1376
Article title

PHYSICOCHEMICAL CHARACTERISTICS OF FUROSEMIDE INCORPORATED EUDRAGIT MICROSPHERES FORMULATED BY SPRAY-DRYING

Content
Title variants
Languages of publication
EN
Abstracts
EN
Microspheres are one of the multicompartment drug delivery systems. The active substance is incorporated into a polymeric matrix. The aim of the study was to determine physicochemical properties of furosemide microspheres prepared with Eudragit L30 D-55 matrix and to analyse their stability and drug release. A test formulation at the drug-polymer ratio of 1:2 was used in the study. Furosemide was incorporated into the enteric matrix because it reduces gastric acid secretion and impairs gastric secretory functions. The optimum spray drying parameters were determined on the basis of preliminary tests: aspirator efficiency: 80%, Tin: 140°C, pump capacity: 10%. The designated Hausner ratio and Carr index indicate good flow properties of the obtained product. The stability tests show that the microspheres are physically stable under the applied storage conditions. Based on the analysis of furosemide release from microspheres, it has been found that it is a two-step process. In the first step, 28.68% of the active substance was released into a pH 1.2 buffer solution. In the second step, the remaining part of the active substance was released into a pH 6.8 buffer within 30 minutes.
Year
Volume
75
Issue
6
Pages
1369-1376
Physical description
Dates
published
2018-12-31
References
Document Type
Publication order reference
Identifiers
YADDA identifier
bwmeta1.element.doi-10_32383_appdr_89799
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