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2018 | 75 | 5 | 1127-1133
Article title

THE RADIOLYTIC STUDIES OF DORIPENEM MONOHYDRATE IN THE SOLID STATE

Content
Title variants
Languages of publication
EN
Abstracts
EN
The influence of ionising radiation on physicochemical properties of doripenem in solid state was studied. No changes for doripenem irradiated with a dose of 25 kGy, required to attain sterility, was observed by FT-IR and chromatographic methods, although the presence of free radicals (7.7*1017 radicals/g) was detected by EPR. The antibacterial activity of doripenem irradiated with a dose of 25 kGy was unchanged. Solid doripenem has proven to be very stable on irradiation, and irradiation has been found to be a suitable method for its sterilization.
Year
Volume
75
Issue
5
Pages
1127-1133
Physical description
Dates
published
2018-10-31
References
Document Type
Publication order reference
Identifiers
YADDA identifier
bwmeta1.element.doi-10_32383_appdr_86757
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