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2018 | 75 | 5 | 1215-1222

Article title

THE STUDY OF ADSORPTION AND DESORPTION OF ANTIBIOTICS ON THE SURFACE OF NANOPARTICLES

Content

Title variants

Languages of publication

EN

Abstracts

EN
Nanotechnology is a field that is gaining more and more importance in the modern world. It uses a particle size of between a few dozen to a few hundred nanometers, or 10-9 meters. It is noted that the use of nanospheres (balls with a diameter of from several to several hundred nm) as carriers of drugs gives an opportunity for their controlled and sustained release. (1,2) Nanospheres as a potential drug carrier for sustained release may enhance the effectiveness of antibiotics. In order to examine the effects of antibiotics with nanospheres an attempt was made to deposit on them three drugs differing in chemical structure. These were chloramphenicol, gentamicin and ceftazidime. The aim of this study was to determine the degree of adsorption of the drug on the surface of nanospheres and to examine the process of desorption from the surface of silica nanoparticles. The results of the study indicate that in the case of chloramphenicol it is essentially a process of chemisorption, and for gentamicin and ceftazidime both physical and chemical adsorption, without there being any clearly defined relationship between this two processes. The purpose of the nanospheres as drug carriers is to obtain controlled and prolonged exposure to the drug. The amount of adsorbed substance depends primarily on its structure. Ceftazidime, as the compound with the highest number of double bonds, and a large number of groups to form hydrogen bonds (carbonyl groups, amino groups), adsorbed to the greatest extent.

Keywords

Year

Volume

75

Issue

5

Pages

1215-1222

Physical description

Dates

published
2018-10-31

Contributors

References

Document Type

Publication order reference

Identifiers

YADDA identifier

bwmeta1.element.doi-10_32383_appdr_86212
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