PL EN


Preferences help
enabled [disable] Abstract
Number of results
2018 | 75 | 4 | 977-987
Article title

QUERCETIN AMELIORATES INSULIN RESISTANCE CONCOMITANT EARLY CARDIOVASCULAR CHANGES IN EXPERIMENTAL RATS

Content
Title variants
Languages of publication
EN
Abstracts
EN
Quercetin is a dietary flavonoid found in a wide range of fruits and vegetables; it has diverse biological activities, possesses beneficial effects in ameliorating diabetic complications, apart from the effect of quercetin on fructose feed induced insulin resistance (IR) linked cardiac dysfunction have not been entirely revealed. This study aspires to explore the effect of quercetin on metabolism, oxidative stress, cardiomyocytes damage and cardiac function in IR state. Wistar rats either sex weighing 220-250 g (n ꞊8), were divided into four groups, kept on either control diet and high fructose diet and supplement with a quercetin as a test drug and metformin as a standard, at the dose of 50 and 200 mg/ kg; p.o., respectively. Daily measured body weight, feed, and water intake for 35 days, Oral glucose tolerance test (OGTT) performed in animals on the 32nd day. At end of the study (36th day), measured hemodynamic parameters after that estimation of various biochemical parameters. Finally, the animals were sacrificed for isolation of tissues and measured heart weight, the oxidative stress level of heart and histopathological changes. Treatment of quercetin with fructose-fed ameliorated all the parameters revile by the contrast of IR rats. The outcome of quercetin associated improves insulin sensitivity, normalized lipid profile, abolish hemodynamic changes, oxidative stress and cardiac injury markers within fructose-fed, and lesser histopathological changes were observed contrast with IR rats. These beneficial effects of quercetin mediated by improving insulin sensitivity and metabolism; reduced oxidative stress could potentially be used to ameliorate the myocardial damage.
Year
Volume
75
Issue
4
Pages
977-987
Physical description
Dates
published
2018-08-31
Contributors
References
Document Type
Publication order reference
Identifiers
YADDA identifier
bwmeta1.element.doi-10_32383_appdr_80887
JavaScript is turned off in your web browser. Turn it on to take full advantage of this site, then refresh the page.