Synthesis and anticancer activity evaluation of some new derivatives of 2-(4-benzoyl-1-piperazinyl)-quinoline and 2-(4-cinnamoyl-1-piperazinyl)-quinoline.

• Authors: Krzysztof P. Kubica , Przemyslaw P. Taciak , Agnieszka Czajkowska , Alicja Sztokfisz-Ignasiak , Rafal Wyrebiak , Piotr Podsadni , Izabela Mlynarczuk-Bialy , Jacek Malejczyk , Aleksander P. Mazurek
• Languages of publication: EN

Abstracts

EN

In this study we designed and synthesized twenty new derivatives of 2-(4-benzoyl-1-piperazinyl)-quinoline and 2-(4-cinnamoyl-1-piperazinyl)-quinoline with potential anticancer activity. The structures of synthesized compounds were confirmed by 1H and 13C NMR spectroscopy and MS spectrometry. The activity of novel compounds was evaluated in the cell viability assay as well as in the wound healing assay. Presented data show that examined substances have anticancer activity in cell culture. Seven compounds which showed a high rate of cell growth inhibition were selected for further studies. Three of them strongly reduced growth of B16F10 cells. The novel compounds constitute a good base for further studies and optimization of structure for new therapeutically effective anti-cancerous drugs.

Keywords

EN

anticancer activity; cytotoxicity assay; 2-quinoline; cell migration assay

• Journal: Acta Poloniae Pharmaceutica - Drug Research
• Year: 2018
• Volume: 75
• Issue: 4
• Pages: 891-901

Dates

published

2018-08-31

Contributors

author

Krzysztof P. Kubica

author

Przemyslaw P. Taciak

author

Agnieszka Czajkowska

author

Alicja Sztokfisz-Ignasiak

author

Rafal Wyrebiak

author

Piotr Podsadni

author

Izabela Mlynarczuk-Bialy

author

Jacek Malejczyk

author

Aleksander P. Mazurek

Identifiers

DOI

10.32383/appdr/80098