Selective arylation of phenol proteted propygyl bromide via pd-catalysed Suzuki coupling reaction: synthesis, mechanistic studies by DFT calculations and Their Pharmacological Aspects"

• Authors: hira farooq , nasir rasool , Muhammad T. Ansari , komal rizwan , tariq mahmood , hira israr , Khurshid Ayub , tahir rasheed , Seema Zareen , muhammad N. Akhtar , sarosh iqbal
• Languages of publication: EN

Abstracts

EN

Biaryls are the potential source of synthetic drugs. The present study describes the synthesis of a series of functionalized biphenyl derivatives (3a-3g) using Pd-catalyzed Suzuki coupling reaction. The experimental results revealed the facile synthesis of biphenyl derivatives (3a-3g) with notably high yield (80-88 %). Density functional theory (DFT) studies were performed by Gaussian 09 software in order to rationalize the selectivity of coupling at C-Br bond instead of C-Cl bond. In addition of synthesis, the biological activities (biofilm inhibition, hemolytic and anti-thrombolytic) of these novel compounds were investigated. These results exhibited good biofilm inhibition (5.86-65.8 %), hemolytic (1.32-30.1 %) and anti-thrombolytic activities (9.64-42.5 %), indicating the potential use of these compounds for pharmaceutical applications.

Keywords

EN

biofilm; phenol; DFT; Suzuki coupling; organoboron; Biaryl

• Journal: Acta Poloniae Pharmaceutica - Drug Research
• Year: 2018
• Volume: 75
• Issue: 4
• Pages: 911-919

Dates

published

2018-08-31

Contributors

author

hira farooq

author

nasir rasool

author

Muhammad T. Ansari

author

komal rizwan

author

tariq mahmood

author

hira israr

author

Khurshid Ayub

author

tahir rasheed

author

Seema Zareen

author

muhammad N. Akhtar

author

sarosh iqbal

Identifiers

DOI

10.32383/appdr/78920