1,3-OXAZOLIDIN-5-ONES DERIVED FROM PROLINE AS CHIRAL COMPONENTS IN THE SYNTHESIS OF PREDICTIVE ENANTIOSELECTIVE COUPLING REAGENTS

• Authors: Katarzyna Kasperowicz-Frankowska , Beata Kolesińska , Anna Gzik , Konrad Jastrząbek , Zbigniew J. Kaminski
• Languages of publication: EN

Abstracts

EN

1,3-Oxazolidin-5-ones derived from both enantiomers of proline and trichloroacetaldehyde were prepared and applied as amine component in the synthesis of chiral predictive triazine based coupling reagents. The usefulness of these reagents in the condensations yielding enantiomerically enriched products from racemic substrates was presented.

Keywords

EN

enantioselective condensation; peptide synthesis; chirality transfer on nitrogen; chiral nitrogen atom; triazine coupling reagent

• Journal: Acta Poloniae Pharmaceutica - Drug Research
• Year: 2018
• Volume: 75
• Issue: 4
• Pages: 921-927

Dates

published

2018-08-31

Contributors

author

Katarzyna Kasperowicz-Frankowska

author

Beata Kolesińska

author

Anna Gzik

author

Konrad Jastrząbek

author

Zbigniew J. Kaminski

Identifiers

DOI

10.32383/appdr/78726