IMPACT OF EXCIPIENTS ON PHARMACEUTICAL AVAILABILITY OF FOLIC ACID FROM TABLETS
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The impact of excipients contained in individual formulations on the pharmaceutical availability of folic acid was investigated. The release rate of the active substance and the disintegration time of the tablets were analysed. It has been found that in the presence of sorbitol, glucose and starch, 100% of folic acid is released within 60 minutes, and in the presence of lactose and starch - 95%, and the release rates for them are 0.0717 min-1 and 0.0555 min-1 respectively.
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