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2020 | 77 | 3 | 453-463
Article title

DEVELEOPMENT AND VALIDATION OFSPECTROFLUOROMETRIC AND SPECTROPHOTOMETRIC BIVARIATE METHODS FOR SIMULTANEOUS DETERMINATION OF PROPRANOLOL AND HYDTOCHLOROTHIAZIDE IN DRUG TABLETS

Content
Title variants
Languages of publication
EN
Abstracts
EN
Spectrofluorometric and spectrophotometric bivariate methods were developed for quantitative of Propranolol and Hydrochlorothiazide in drug tablets in aqueous medium. The methods were tested according to ICH guidelines for linearity, recovery, and specificity and were found accurate, precise, sensitive, and free from interferences. The linearity was established over the ranges 0.025–0.30 and 0.010–0.20 mg/L in the first method, and 1.0–20.0 and 5.0–25.0 mg/L in second method, for PRO and HCT, respectively. The excitation and emission wavelengths were 260, 345 and 270, 415 nm, for PRO and HCT in the first method, respectively. The recoveries were higher than 95% for both methods. Additionally, the results were statistically compared to that of standard chromatographic methods and showed that no significant difference among the methods regarding both accuracy and precision. Thus, the methods were successfully applied to quantitation of PRO and HCT in combined formulations. The proposed methods are reliable, simple, sensitive, and adaptable and could effectively be an alternative method to HPLC.
Year
Volume
77
Issue
3
Pages
453-463
Physical description
Dates
published
2020-06-29
Contributors
References
Document Type
Publication order reference
Identifiers
YADDA identifier
bwmeta1.element.doi-10_32383_appdr_123019
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