MRI as a potential tool for monitoring of therapeutic monoclonal antibody distribution in cancer patients

• Authors: Jacek Tabarkiewicz , David Aebisher , Dorota Bartusik-Aebisher
• Languages of publication: EN

Abstracts

EN

Imaging and quantification of MAbs distribution by MRI after administration in vivo can improve patient outcomes, although it is not routinely used in the clinic hence the motivation for development of new MAbs imaging methodologies. Improvements in imaging and quantification of antibody distributions can be made by conjugating MAbs to “hotspot” atoms such as 19F as 19F Currently, research investigating the incorporation of 19F to antibody delivery systems has been limited to trastuzumab perfluorocarbon emulsions and this method has not been extended to other clinically approved antibodies. The methodologies of 19F MRI can improve current limitations of antibody immunotherapy such as quantitative visualization of targeted surface antigens expressed on tumor cells.

Keywords

EN

monoclonal antibody; magnetic resonance imaging; fluorine; cancer diagnostics

• Journal: Acta Poloniae Pharmaceutica - Drug Research
• Year: 2020
• Volume: 77
• Issue: 3
• Pages: 383-389

Dates

published

2020-06-29

Contributors

author

Jacek Tabarkiewicz

author

David Aebisher

author

Dorota Bartusik-Aebisher

Identifiers

DOI

10.32383/appdr/119981