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2020 | 77 | 3 | 465-473

Article title

EVALUATION OF MUTAGENIC PROPERTIES OF 2(C6H15N2O2)+2I3-H2O IODINE COORDINATION COMPLEX IN BACTERIAL REVERSE MUTATION TEST

Content

Title variants

Languages of publication

EN

Abstracts

EN
Objective: 2(C6H15N2O2)+ 2I3-H2O iodine coordination complex is a new pharmaceutical substance that have high antibacterial activity against both sensitive and multidrug resistant strains of Escherichia coli, Staphylococcus aureus, Pseudomonas aeruginosa. Methods: Mutagenicity of 2(C6H15N2O2)+2I3-H2O iodine coordination complex was assessed using Salmonella/microsome (Ames) test. Tester strains used were Salmonella typhimurium TA98, TA100, TA1535, TA 1537 and Escherichia coli WP2uvrA. The mutagenic activity was determined both in the absence or presence of S9 mixture. Results: The study have shown that test item did not cause any increase in the number of his+ revertants in S.typhimurium and trp+revertants in E.coli WP2uvrA strains in the presence or absence of S9-mix, compared to the controls. Conclusion: Under the conditions of this test and according to the criteria set for the evaluation of the test results, the 2(C6H15N2O2)+ 2I3-H2O iodine coordination complex did not show mutagenic activity in the S. typhimurium and E.coli plate incorporation assay.

Year

Volume

77

Issue

3

Pages

465-473

Physical description

Dates

published
2020-06-29

References

Document Type

Publication order reference

Identifiers

YADDA identifier

bwmeta1.element.doi-10_32383_appdr_119343
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