Novel Aryl/Alkyl Azole Derivates as an anti-nociceptive and anti-inflammatory drug candidates

• Authors: Yesim Kaya-Yasar , Elif N. Barut , Seckin Engin , Inci S. Dogan , Feride S. Sezen
• Languages of publication: EN

Abstracts

EN

Novel aryl/alkyl azole derivative compounds C1 and C2 were screened for in vivo anti-nociceptive and anti-inflammatory activities by using the hot plate test and formalin-induced hind paw edema test, respectively. Ability of these compounds to inhibit cyclooxygenase-1/2 (COX-1/2) and 5/15-lipoxygenase (5/15-LOX) were evaluated in vitro by using a colorimetric method. C1 (30 and 50 mg/kg, i.p.) and C2 (3 and 30 mg/kg, i.p.) increased the latency to withdrawal in the hot plate test, indicating an anti-nociceptive activity. C1(30 and 50 mg/kg) and C2 (3,30 and 50 mg) were able to decrease formalin-induced edema, indicating their anti-inflammatory properties. C1 and C2 exhibited inhibitory effects on the activity of COX(1-2) and 15-LOX. However, neither C1 nor C2 showed an inhibitory effect on 5-LOX. This study demonstrates that C1 and C2 have anti-nociceptive and anti-inflammatory activities, that is partially mediated by inhibition of COX and LOX enzymes. Our results suggest that C1 and C2, novel aryl/alkyl azole compounds, could serve as lead compounds to develop novel therapeutic options for the treatment of pain and inflammation.

Keywords

EN

pain; inflammation; aryl/alkyl azole; COX-LOX; formalin-induced hind paw edema test; hot plate test

• Journal: Acta Poloniae Pharmaceutica - Drug Research
• Year: 2020
• Volume: 77
• Issue: 2
• Pages: 289-294

Dates

published

2020-04-29

Contributors

author

Yesim Kaya-Yasar

author

Elif N. Barut

author

Seckin Engin

author

Inci S. Dogan

author

Feride S. Sezen

Identifiers

DOI

10.32383/appdr/118364