The radiolytic studies of panipenem in the solid state

• Authors: Przemysław Zalewski , Natalia Rosiak , Karolina Kilińska , Robert Skibiński , Daria Szymanowska , Ewa Tykarska , Lidia Piekara-Sady , Kornelia Lewandowska , Andrzej Miklaszewski , Judyta C. Piontek
• Languages of publication: EN

Abstracts

EN

The influence of ionizing radiation on the physicochemical properties of panipenem in solid state was studied. In the first part of our studies, we evaluated the possibility of applying radiosterilization to obtain sterile panipenem. Spectroscopic (FT-IR, Raman), chromatography (HPLC and HPLC-MS) and X-ray powder diffraction (XRPD) studies have shown that irradiation of ertapenem with the 25 kGy, the dose required to achieve sterility, does not change the physicochemical properties of the studied compound. The antimicrobial activity of panipenem irradiated with the dose of 25 kGy was reduced for three species. It was confirmed that the decrease in antimicrobial activity might be related to isomerization of panipenem.

Keywords

EN

HPLC; FT-IR; EPR; radiation sterilization; Q-TOF; panipenem

• Journal: Acta Poloniae Pharmaceutica - Drug Research
• Year: 2020
• Volume: 77
• Issue: 2
• Pages: 241-250

Dates

published

2020-04-29

Contributors

author

Przemysław Zalewski

author

Natalia Rosiak

author

Karolina Kilińska

author

Robert Skibiński

author

Daria Szymanowska

author

Ewa Tykarska

author

Lidia Piekara-Sady

author

Kornelia Lewandowska

author

Andrzej Miklaszewski

author

Judyta C. Piontek

Identifiers

DOI

10.32383/appdr/117889