PL EN


Preferences help
enabled [disable] Abstract
Number of results
2020 | 77 | 1 | 89-98
Article title

Vanadium rutin complex sensitizes breast cancer cells via modulation of p53/Bax/Bcl2/VEGF correlated with apoptotic events

Content
Title variants
Languages of publication
EN
Abstracts
EN
In pursuit of a novel approach in breast cancer therapy, we explored the ability of vanadium rutin complex to eradicate cancer by efficiently targeting various apoptotic pathways on human breast cancer cell lines. We provide direct proof of the chemotherapeutic potential of vanadium rutin complex by activating p-53 dependent intrinsic apoptosis and modulating the VEGF pathways. The complex was also capable of binding and cleaving CT-DNA at different concentration. The complex was able to inhibit cell viability at 100 and 150 ┬ÁM doses in both MCF7 and MDA-MB-231 cells. Furthermore, the complex successfully initiated apoptosis in both cell lines by activating the p53 dependant intrinsic apoptotic pathway. In-vitro studies also established that the complex modulated p53, Bax, Bcl2 and VEGF expressions and induced DNA fragmentation in both the cell lines.
Year
Volume
77
Issue
1
Pages
89-98
Physical description
Dates
published
2020-02-29
Contributors
author
author
author
author
author
References
Document Type
Publication order reference
Identifiers
YADDA identifier
bwmeta1.element.doi-10_32383_appdr_115158
JavaScript is turned off in your web browser. Turn it on to take full advantage of this site, then refresh the page.