Effect of Solublising Aids on The Entrapment of Loratidine in Pre-Fabricated PVA Filaments Used for FDM Based 3D-Printing

• Authors: Faisal Mahmood , Amjad Hussain , Muhammad Sohail Arshad , Nasir Abbas , Muhammad Irfan , Nadia Qamar , Fahad Hussain , Muhammad Usman Ghori
• Languages of publication: EN

Abstracts

EN

Low drug loading efficiency is the limiting factor in the use of pre-fabricated filaments for 3D printing of pharmaceuticals. The aim of present study was to modify the material properties of pre-fabricated filament by incorporating the suitable solubilizing aids in order to enhance the drug loading efficiency. Loratadine was loaded into PVA filaments by using solubilizers (Soluplus®, Sodium lauryl sulphate) and plasticizers (glycerin and Polyethylene glycol-400) and the printability of filaments was investigated. The treated filaments were characterized for morphology and diameter changes, drug content, FTIR and thermal properties and printed into tablets of suitable dimensions. The printed tablets were also characterized for drug assay and drug release. The results have shown that the surface of different drug loaded filaments become rough with almost no change in diameter hence, these filaments remained printable. However, there was 7 to 24 times enhancement in drug content of filaments treated with particularly those pretreated with glycerin and soaked in drug solution containing Soluplus. The printed tablets have also shown almost similar drug content as their precursor filaments and the release followed diffusion mechanism in most of the formulations. The study concludes that the treatment of PVA filament with solubilizer aids has significantly improved the drug loading entrapment without compromising the printability.

Keywords

EN

3D printing; Plasticizers; Fused deposition modelling (FDM); PVA filaments; Solubilizers

• Journal: Acta Poloniae Pharmaceutica - Drug Research
• Year: 2020
• Volume: 77
• Issue: 1
• Pages: 175-182

Dates

published

2020-02-29

Contributors

author

Faisal Mahmood

author

Amjad Hussain

author

Muhammad Sohail Arshad

author

Nasir Abbas

author

Muhammad Irfan

author

Nadia Qamar

author

Fahad Hussain

author

Muhammad Usman Ghori

Identifiers

DOI

10.32383/appdr/113596