PL EN


Preferences help
enabled [disable] Abstract
Number of results
2020 | 77 | 1 | 131-143
Article title

ANALYSIS OF POLYPHENOLIC COMPOSITION AND STABILITY OF MAGISTRAL PREPARATION BASED ON SALVIAE OFFICINALIS FOLIUM

Content
Title variants
Languages of publication
EN
Abstracts
EN
A magistral preparation based on the sage leaf decoction or infusion is one of the most popular herbal prescription prepared in pharmacies in Lower Silesia (Poland) for gargling in the pharyngitis or mouth infections. Other components of this preparation are boric acid, aluminum(III) acetotartrate or Burow's solution, and glycerol. The study aimed to investigate the polyphenolic composition and relations between herbal and chemical ingredients that are present in this mixture in comparison with the traditional aqueous galenic forms – infusion and decoction. The analysis was performed using HPLC-DAD and ESI-MS methods. The main polyphenolic ingredients of sage leaf were rosmarinic acid and luteolin 7-O-β-glucuronide. The content of analyzed polyphenols was higher in the decoction than in the infusion. The pharmacological activity of the examined mixture results from the presence of boric acid, aluminum(III) salts and polyphenolic components of sage leaf. The study showed that in the presence of excess salts of aluminum(III) and boric acid, sage polyphenols are partially soluble in an aqueous medium (mainly phenolic acids) and complexed as precipitated sediment (especially flavonoids). The aqueous solutions of this preparation are cloudy, which suggests limited solubility of the formed complexes. Therefore, the therapeutic activity of the sage leaf magistral preparation should be associated with the presence of water soluble caffeic acid esters like rosmarinic acid. The influence of luteolin glycosides coordination complexes is not evident. The obtained results also confirm the stability of the examined formula in the conditions of cold storage (4-6 °C) within 7 days from its production.
Year
Volume
77
Issue
1
Pages
131-143
Physical description
Dates
published
2020-02-29
Contributors
References
Document Type
Publication order reference
Identifiers
YADDA identifier
bwmeta1.element.doi-10_32383_appdr_112832
JavaScript is turned off in your web browser. Turn it on to take full advantage of this site, then refresh the page.