PL EN


Preferences help
enabled [disable] Abstract
Number of results
2019 | 76 | 6 | 1061-1071
Article title

QUALITY ANALYSIS OF SEMISOLID FORMULATIONS WITH ELDERFLOWER (SAMBUCUS NIGRA L.) LIQUID EXTRACT

Content
Title variants
Languages of publication
EN
Abstracts
EN
The active ingredients in the Elderflower liquid extract are responsible for the antibacterial, antioxidant and anti-inflammatory effects of the plant. The aim of the study was to design semisolid formulations with liquid Elderflower extract and evaluate the quality of them using a biopharmaceutical research method in vitro. The quality of the Elderflower (Sambucus nigra L.) extracts were evaluated spectrophotometrically by determining the total polyphenols and flavonoids content. Antiradical activity was determined by employing the spectrophotometrically DPPH free radical scavening method. Antibacterial activity was determined in vitro using the agar diffusion method. The biopharmaceutical experiment in vitro of the semisolid pharmaceutical formulations was performed by using modified Franz type diffusion cells. The results revealed that the highest amount of active compounds were found in the extracts when 70% (v/v) ethanol was used for the extraction of the raw material. The extracts obtained have antiradical activity and antimicrobial effects against S. aureus and B. cereus. Released amount of active compounds decreased when oleogel concentration in the formulation increased. The in vitro results of a biopharmaceutical semisolid formulation study showed that the base and the amount of excipients affected the release kinetics of the active compounds from the formulations. The results of the study showed that, as the lipophilicity and viscosity of the base increase, the formulation is characterized by a prolonged action: the release of the flavonoids, with the increase in the amount of oleogel, slow down. The best carrier of ederflower liquid extract was confirmed the hydrophilic base.
Year
Volume
76
Issue
6
Pages
1061-1071
Physical description
Dates
published
2019-12-29
Contributors
References
Document Type
Publication order reference
Identifiers
YADDA identifier
bwmeta1.element.doi-10_32383_appdr_112052
JavaScript is turned off in your web browser. Turn it on to take full advantage of this site, then refresh the page.