THE POSSIBILITY OF USING X-RAY POWDER DIFFRACTION, INFRARED AND RAMAN SPECTROSCOPY IN THE STUDY OF THE IDENTIFICATION OF STRUCTURAL POLYMORPHS OF ACETAMINOPHEN

• Authors: Anna Stasiłowicz , Mikołaj Mizera , Ewa Tykarska , Kornelia Lewandowska , Andrzej Miklaszewski , Judyta Cielecka-Piontek
• Languages of publication: EN

Abstracts

EN

Paracetamol (acetaminophen), a pain-killer with antipyretic properties, shows structural polymorphism. It occurs in three polymorphic forms: monoclinic, orthorhombic, and unstable form III. In the study, the commercially available samples of paracetamol (P1 and P2) were examined using X-ray powder diffraction, infrared, and Raman spectroscopy. Results demonstrated that all of the methods defined polymorphic forms of paracetamol in the samples. However, only Raman spectroscopy and PXRD methods detected impurities in the sample P1. These methods transpired to be more sensitive than the FT-IR method, which identified samples of paracetamol as one structural form (monoclinic polymorph). Moreover, the Raman spectroscopy identified impurities in the form P1 as changes in the crystalline form.

Keywords

EN

acetaminophen; PXRD; Raman; FT-IR; structural polymorphism

• Journal: Acta Poloniae Pharmaceutica - Drug Research
• Year: 2019
• Volume: 76
• Issue: 6
• Pages: 997-1004

Dates

published

2019-12-29

Contributors

author

Anna Stasiłowicz

author

Mikołaj Mizera

author

Ewa Tykarska

author

Kornelia Lewandowska

author

Andrzej Miklaszewski

author

Judyta Cielecka-Piontek

Identifiers

DOI

10.32383/appdr/110690