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2019 | 76 | 4 | 701-706
Article title

CYTOTOXIC ACTIVITY OF VARTHEMIA IPHIONOIDES ESSENTIAL OIL AGAINST VARIOUS HUMAN CANCER CELL LINES

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Title variants
Languages of publication
EN
Abstracts
EN
Varthemia iphionoides is a perennial plant that belongs to Asteraceae family. This study investigates the cytotoxic effect of V. iphionoides essential oil on breast (MCF7), prostate (PC3), and chronic myelogenous leukemia (K562) and normal human fibroblast cell lines using MTT assay and flow cytometric analysis. In addition, GC-MS of the oil was carried out. The IC50 values for PC3, MCF7, K562 and fibroblast were 145.3, 188.8, 87.88 and 173.3 µg/ml, respectively. V. iphionoides essential oil was most effective against K562. Flow cytometric results for IC50 dose of V. iphionoides oil on K562 cells showed 32.2 % apoptosis in 24 h. GC-MS analysis resulted in the identification of 25 compounds. 1,8-Cineole, borneol, and α-cadinol were the major constituents of V. iphionoides volatile oil. In conclusion, this study reveals for the first time the cytotoxic activity of V. iphionoides essential oil on K562 cell line which may occur through apoptosis induction.
Year
Volume
76
Issue
4
Pages
701-706
Physical description
Dates
published
2019-08-30
Contributors
References
Document Type
Publication order reference
Identifiers
YADDA identifier
bwmeta1.element.doi-10_32383_appdr_105777
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