ASSESSMENTS OF ANTIOXIDANT CONTENT AND THE ANTI-CARCINOGENIC EFFECT OF EXTRACTS OF SOLANUM ROSTRATUM DUNAL IN HUMAN CANCER CELLS

• Authors: María del Carmen Valadez Vega , Jeannett Alejandra Izquierdo Vega , Jose Roberto Villagómez Ibarra , Manuel Sánchez Gutiérrez , Eduardo Osiris Madrigal Santillán , Jose Antonio Morales Gonzalez , Mirandeli Bautista Ávila , Laura García Velasco
• Languages of publication: EN

Abstracts

EN

In Mexico, Solanum rostratum has been employed for the treatment of several diseases, including uterine cancer. The aim of this study was to evaluate the antioxidant and anti-carcinogenic activity of extracts of Solanum rostratum Dunal on MDA and SiHa cell lines. The methanolic, ethyl acetate, and hexane extracts of the aerial parts of Solanum rostratum were tested for phenols concentration, antioxidant activity, and anti-carcinogenic effect. The leaves extracts showed the highest content of phenols; however the flower-fruits extracts showed higher scavenging activity. On the other hand, ethyl acetate extracts exhibited the highest anti-carcinogenic effect, while methanolic extracts showed the least effect. The results of this work indicated that Solanum rostratum is a promising source of antioxidants, and the extracts exert a dose-dependent anti-carcinogenic effect on both cell lines.

Keywords

EN

antioxidant; cytotoxic; Solanum rostratum; SiHa cell line; MDA cell line

• Journal: Acta Poloniae Pharmaceutica - Drug Research
• Year: 2019
• Volume: 76
• Issue: 3
• Pages: 493-502

Dates

published

2019-06-28

Contributors

author

María del Carmen Valadez Vega

author

Jeannett Alejandra Izquierdo Vega

author

Jose Roberto Villagómez Ibarra

author

Manuel Sánchez Gutiérrez

author

Eduardo Osiris Madrigal Santillán

author

Jose Antonio Morales Gonzalez

author

Mirandeli Bautista Ávila

author

Laura García Velasco

Identifiers

DOI

10.32383/appdr/100501