THE RADIATION STERILIZATION OF IMIPENEM AND CILASTATIN IN THE SOLID STATE

• Authors: Przemysław Zalewski , Karolina Kilińska , Judyta C. Piontek , Andrzej Miklaszewski , Daria Szymanowska , Robert Skibiński , Waldemar Bednarski
• Languages of publication: EN

Abstracts

EN

One of the best sterilization methods for chemically unstable drugs, such as carbapenems, is irradiation. The chemical and physical properties of radiosterilized imipenem and cilastatin were analyzed using spectrophotometric and chromatographic methods. Unstable free radicals were presented in samples after irradiation; their mean lifetime was 142±64 h. The antibacterial activity of cefozopran hydrochloride irradiated with a dose of 25 kGy changed for Klebsiella pneumoniae and Escherichia coli. Imipenem and cilastatin in the solid state are not resistant to radiation sterilization; therefore, this method cannot be used for sterilization of this compound.

Keywords

EN

imipenem; radiation sterilization; microbiological activity; radiostability; Q-TOF

• Journal: Acta Poloniae Pharmaceutica - Drug Research
• Year: 2019
• Volume: 76
• Issue: 3
• Pages: 431-438

Dates

published

2019-06-28

Contributors

author

Przemysław Zalewski

author

Karolina Kilińska

author

Judyta C. Piontek

author

Andrzej Miklaszewski

author

Daria Szymanowska

author

Robert Skibiński

author

Waldemar Bednarski

Identifiers

DOI

10.32383/appdr/100459