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2019 | 76 | 3 | 431-438
Article title

THE RADIATION STERILIZATION OF IMIPENEM AND CILASTATIN IN THE SOLID STATE

Content
Title variants
Languages of publication
EN
Abstracts
EN
One of the best sterilization methods for chemically unstable drugs, such as carbapenems, is irradiation. The chemical and physical properties of radiosterilized imipenem and cilastatin were analyzed using spectrophotometric and chromatographic methods. Unstable free radicals were presented in samples after irradiation; their mean lifetime was 142±64 h. The antibacterial activity of cefozopran hydrochloride irradiated with a dose of 25 kGy changed for Klebsiella pneumoniae and Escherichia coli. Imipenem and cilastatin in the solid state are not resistant to radiation sterilization; therefore, this method cannot be used for sterilization of this compound.
Year
Volume
76
Issue
3
Pages
431-438
Physical description
Dates
published
2019-06-28
References
Document Type
Publication order reference
Identifiers
YADDA identifier
bwmeta1.element.doi-10_32383_appdr_100459
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