Preferences help
enabled [disable] Abstract
Number of results
2019 | 1 | 2 | 11-16
Article title

The use of over-the-counter analgesics in patients with chronic kidney disease

Title variants
Languages of publication
Background Analgesics can be sold following medical prescription, but also as over-the-counter (OTC) medications. In patients with chronic kidney disease (CKD), their use could potentially be associated with increased risk of side-effects, due to impaired renal elimination. The aim was to evaluate the epidemiology and indications for the use of OTC analgesics, and the knowledge of their side-effects in patients with CKD. Material and methods A cross-sectional, controlled survey on the use of OTC analgesic drugs was conducted among 180 CKD patients (stage 1-5, dialysis, kidney transplant), compared to 60 controls. Results The proportion of patients using OTC analgesics on a regular basis was higher in the CKD group, compared to controls (18.9% vs. 10.0%, p<0.02). The major indications included musculoskeletal issues, followed by headaches and other. Subgroup analysis revealed that analgesic use was lowest among transplanted patients, in comparison to CKD stage 1-5, and dialysis subjects (10%, 20%, 26%, respectively, p=0.06). Less than half of CKD patients and controls declared any knowledge on potential side-effects of analgesic drugs (45.6% vs. 40.0%, NS). Conclusions The use of OTC analgesics among patients with CKD is higher than in subjects without CKD, with the exception of transplanted patients. The knowledge on the potential side-effect of analgesics is limited.
Physical description
  • \Villako P, Volmer D, Raal A: Factors influencing purchase of and counselling about prescription and OTC medicines at community pharmacies in Tallinn, Estonia. Acta Pol Pharm. 2012;69(2):335-40.
  • Sado E, Kassahun E, Bayisa G et al.: Epidemiology of self-medication with modern medicines among health care professionals in Nekemte town, western Ethiopia. BMC Res Notes. 2017;10(1):533.
  • Bjarnason I: Gastrointestinal safety of NSAIDs and over-the-counter analgesics. Int J Clin Pract Suppl. 2013;(178):37-42.
  • Zdrojewski L, Zdrojewski T, Rutkowski M et al.: Prevalence of chronic kidney disease in a representative sample of the Polish population: results of the NATPOL 2011 survey. Nephrol Dial Transplant. 2016;31(3):433-39.
  • National Kidney F: K/DOQI clinical practice guidelines for chronic kidney disease: evaluation, classification, and stratification. Am J Kidney Dis. 2002;39(2 Suppl 1):S1-266.
  • Levey AS, Stevens LA, Schmid CH et al.: A new equation to estimate glomerular filtration rate. Ann Intern Med. 2009;150(9):604-612.
  • Hamilton K, Davis C, Falk J, Singer A, Bugden S: High risk use of OTC NSAIDs and ASA in family medicine: A retrospective chart review. Int J Risk Saf Med. 2015;27(4):191-99.
  • Hudec R, Bozekova L, Tisonova J: Consumption of three most widely used analgesics in six European countries. J Clin Pharm Ther. 2012;37(1):78-80.
  • Hider-Mlynarz K, Cavalie P, Maison P: Trends in analgesic consumption in France over the last 10 years and comparison of patterns across Europe. Br J Clin Pharmacol. 2018;84(6):1324-34.
  • Stiel D: Exploring the link between gastrointestinal complications and over-the-counter analgesics: current issues and considerations. Am J Ther. 2000;7(2):91-98.
  • Wu J, Ginsberg JS, Zhan M et al.: Chronic pain and analgesic use in CKD: implications for patient safety. Clin J Am Soc Nephrol. 2015;10(3):435-42.
  • Murray TG,Goldberg M: Analgesic-associated nephropathy in the U.S.A.: epidemiologic, clinical and pathogenetic features. Kidney Int. 1978;13(1):64-71.
  • Stewart JH: Analgesic abuse and renal failure in Australasia. Kidney Int. 1978;13(1):72-78.
  • Chmielewski M, Jakimowicz-Tylicka M, Rutkowski B: Analgesics – still a nephrological cause for concern? Forum Nefrol. 2015;8(2):43-48.
Document Type
Publication order reference
YADDA identifier
JavaScript is turned off in your web browser. Turn it on to take full advantage of this site, then refresh the page.