Preferences help
enabled [disable] Abstract
Number of results
2020 | 3 | 1 | 34-42
Article title

Anthropometric measurements, nutritional status and body composition in children with cystic fibrosis – the prospective study

Title variants
Languages of publication
Background Cystic fibrosis(CF),despite much progress in therapy, remains the disease which affects nutrition. Nutrition is an important prognostic factor of the outcome of the disease. We want to evaluate physical development, nutrition and body composition in CF children. Material and methods 75 children diagnosed with CF (9 months to 18 years old) were included into the study. 33 healthy children (9 months to 18 years old) constituted the control group. The study consisted of 2 stages. In the first the differences between groups were investigated. The second, took place a year later. At each time point the following measurements were performed: height, body mass, skin fold, arm circumference; BMI, FFM%, FM% and Frisancho index. FFM(fat free mass), FM(fat mass), muscle mass, TBW(total body water) were evaluated by mans of BIA(bioimpedance). Results CF children were shorter than healthy children. Stunting affected 18,67% of CF patients at first examination and 21,6% a year later. Underweight was diagnosed in 28% of patients at the beginning and in 41.2% a year after. Underweight was the result of both little FM and scarce muscle mass. Conclusions Many children with cystic fibrosis suffers from short stature and underweight, which progresses within time. FFM decreases with the disease progress
Physical description
  • Pencharz PB, Durie PR. Pathogenesis of malnutrition in cystic fibrosis, and its treatment. Clin Nutr [Internet]. 2000 Dec;19(6):387–94. Available from:
  • Walkowiak J, Pogorzelski A, Sands D. Zasady rozpoznawania i leczenia mukowiscydozy. [The principles of diagnosing and treatment of cystic fibrosis]. Zalecenia Polskiego Towarzystwa Mukowiscydozy. 2009.
  • Martin R, Saller K. Lehrbuch der Anthropologie, in systematischer Darstellung. Stuttgart: Fischer; 1957.
  • Palczewska I, Niedzwiedzka Z. Wskazniki rozwoju somatycznego dzieci I mlodziezy Warszawskiej. Med Wieku Rozw / Dev Period Med. 2001;5(2 Suppl 1):18–118.
  • Design of the WHO multicentre growth refrence study. Methodology [Internet]. 2015. Available from:
  • International Pediatric Association Endorsement The New WHO Growth Standards for Infants and Young Children [Internet]. 2006. Available from:
  • Slaughter MH, Lohman TG, Boileau R, Horswill CA, Stillman RJ, Van Loan MD, et al. Skinfold equations for estimation of body fatness in children and youth. Hum Biol [Internet]. 1988;60(5):709–23. Available from:
  • Frisancho AR. Triceps skin fold and upper arm muscle size norms for assessment of nutritional status. Am J Clin Nutr [Internet]. 1974 Oct 1;27(10):1052–8. Available from:
  • Lewitt A, Mądro E, Krupienicz A. Podstawy teoretyczne i zastosowania analizy impedancji bioelektrycznej (BIA). Endokrynol Otyłość i Zaburzenia Przemiany Mater. 2007;2(4):79–84.
  • McKay KO. Cystic fibrosis: Benefits and clinical outcome. J Inherit Metab Dis [Internet]. 2007 Aug 1;30(4):544–55. Available from:
  • Sobczyńska-Tomaszewska A, Ołtarzewski M, Czerska K, Wertheim-Tysarowska K, Sands D, Walkowiak J, et al. Newborn screening for cystic fibrosis: Polish 4 years’ experience with CFTR sequencing strategy. Eur J Hum Genet [Internet]. 2013;21(4):391–6. Available from:
  • Walkowiak J, Krawczyński M, Gawęcki J. Nieuchronne niedożywienie [Internet]. Serwis Mukowiscydoza. [cited 2020 Apr 20]. Available from: CUR ID=281&return=archives.
  • Sharma R, Florea VG, Bolger AP, Doehner W, Florea ND, Coats AJS, et al. Wasting as an independent predictor of mortality in patients with cystic fibrosis. Thorax [Internet]. 2001 Oct 1;56(10):746 LP – 750. Available from:
  • Tutak-Słupska M, Stępień-Jaszowska B, Staszak-Kowalska R, Krawczyk-Karlińska J, Zając M. Ocena stanu odżywienia i składu ciała pacjentów z mukowiscydozą. Pediatr Pol [Internet]. 2012;87(2):146–53. Available from:
  • Walkowiak J. Stan odżywienia i rozwój fizyczny dzieci chorych na mukowiscydozę w świetle podstawowych wskaźników wagowych i wzrostowych. Przegląd Pediatryczny. 1998;28(3):208–12.
  • Szczepanik M, Krawczyński M, Cichy W, Walkowiak J. Rozwój fizyczny dzieci z mukowiscydozą z województwa wielkopolskiego. Ped Prakt. 2000;8:397–410.
  • Beaumesnil M, Chaillou E, Wagner A-C, Rouquette A, Audran M, Giniès J-L. Composition corporelle des patients mucoviscidosiques – comparaison de 3 techniques de mesure : anthropométrie, absorptiométrie biphotonique et impédancemétrie. Arch Pédiatrie [Internet]. 2011 Apr;18(4):370–5. Available from:
  • King S, Wilson J, Kotsimbos T, Bailey M, Nyulasi I. Body composition assessment in adults with cystic fibrosis: comparison of dual-energy X-ray absorptiometry with skinfolds and bioelectrical impedance analysis. Nutrition [Internet]. 2005 Nov;21(11–12):1087–94. Available from:
  • Charatsi AM, Dusser P, Freund R, Maruani G, Rossin H, Boulier A, et al. Bioelectrical impedance in young patients with cystic fibrosis: Validation of a specific equation and clinical relevance. J Cyst Fibros [Internet]. 2016;15(6):825–33. Available from:
  • Sheikh S, Zemel BS, Stallings VA, Rubenstein RC, Kelly A. Body Composition and Pulmonary Function in Cystic Fibrosis [Internet]. Vol. 2, Frontiers in Pediatrics . 2014. p. 33. Available from:
  • Doulgeraki A, Petrocheilou A, Petrocheilou G, Chrousos G, Doudounakis S-E, Kaditis AG. Body composition and lung function in children with cystic fibrosis and meconium ileus. Eur J Pediatr [Internet]. 2017;176(6):737–43. Available from:
  • Alvarez JA, Ziegler TR, Millson EC, Stecenko AA. Body composition and lung function in cystic fibrosis and their association with adiposity and normal-weight obesity. Nutrition [Internet]. 2016;32(4):447–52. Available from:
  • Papalexopoulou N, Dassios TG, Lunt A, Bartlett F, Perrin F, Bossley CJ, et al. Nutritional status and pulmonary outcome in children and young people with cystic fibrosis. Respir Med [Internet]. 2018 Sep;142:60–5. Available from:
  • Cahill Jr GF. Starvation in man. N Engl J Med [Internet]. 1970;282(12):668–75. Available from:
  • Miller M, Ward L, Thomas BJ, Cooksley WG, Shepherd RW. Altered body composition and muscle protein degradation in nutritionally growth-retarded children with cystic fibrosis. Am J Clin Nutr [Internet]. 1982 Sep 1;36(3):492–9. Available from:
  • Umławska W, Krzyżanowska M, Zielińska A, Sands D. Effect of selected factors associated with the clinical corse of disease on nutritional status in children with cystic fibrosis. Adv Clin Exp Med [Internet]. 2014;23(5):775–83. Available from:
  • Rothkopf MM, Stanislaus G, Haverstick L, Kvetan V, Askanazi J. Invited Review: Nutritional Support in Respiratory Failure. Nutr Clin Pract. 1989;4(5):166–72.
  • Enright S, Chatham K, Ionescu AA, Unnithan VB, Shale DJ. The influence of body composition on respiratory muscle, lung function and diaphragm thickness in adults with cystic fibrosis. J Cyst Fibros [Internet]. 2007;6(6):384–90. Available from:
  • Lazarus R, Gore CJ, Booth M, Owen N. Effects of body composition and fat distribution on ventilatory function in adults. Am J Clin Nutr [Internet]. 1998 Jul 1;68(1):35–41. Available from:
  • Mohamed EI, Maiolo C, Iacopino L, Pepe M, Daniele N, Lorenzo A. The Impact of Body-Weight Components on Forced Spirometry in Healthy Italians. Lung [Internet]. 2002 May 27;180(3):149–59. Available from:
  • Ionescu AA, Chatham K, Davies CA, Nixon LS, Enright S, Shale DJ. Inspiratory Muscle Function and Body Composition in Cystic Fibrosis. Am J Respir Crit Care Med [Internet]. 1998 Oct;158(4):1271–6. Available from:
  • Ionescu AA, Nixon LS, Luzio S, Lewis-Jenkins V, Evans WD, Stone MD, et al. Pulmonary Function, Body Composition, and Protein Catabolism in Adults with Cystic Fibrosis. Am J Respir Crit Care Med [Internet]. 2002 Feb 15;165(4):495–500. Available from:
  • Calella P, Valerio G, Brodlie M, Donini LM, Siervo M. Cystic fibrosis, body composition, and health outcomes: a systematic review. Nutrition [Internet]. 2018 Nov;55–56:131–9. Available from:
  • Shepherd R, Cooksley WGE, Cooke WDD. Improved growth and clinical, nutritional, and respiratory changes in response to nutritional therapy in cystic fibrosis. J Pediatr [Internet]. 1980 Sep;97(3):351–7. Available from:
  • Shei R-J, Mackintosh KA, Peabody Lever JE, McNarry MA, Krick S. Exercise Physiology Across the Lifespan in Cystic Fibrosis. Front Physiol [Internet]. 2019 Nov 5;10:1382. Available from:
  • Selvadurai HC, Blimkie CJ, Meyers N, Mellis CM, Cooper PJ, Van Asperen PP. Randomized controlled study of in-hospital exercise training programs in children with cystic fibrosis. Pediatr Pulmonol [Internet]. 2002 Mar 1;33(3):194–200. Available from:
  • Orenstein DM, Hovell MF, Mulvihill M, Keating KK, Hofstetter CR, Kelsey S, et al. Strength vs aerobic training in children with cystic fibrosis. Chest [Internet]. 2004 Oct;126(4):1204–14. Available from:
  • Klijn PHC, Oudshoorn A, van der Ent CK, van der Net J, Kimpen JL, Helders PJM. Effects of anaerobic training in children with cystic fibrosis: a randomized controlled study. Chest [Internet]. 2004;125(4):1299–305. Available from:
Document Type
Publication order reference
YADDA identifier
JavaScript is turned off in your web browser. Turn it on to take full advantage of this site, then refresh the page.