OLEOGELS AND BIGELS AS TOPICAL DRUG CARRIERS FOR KETOCONAZOLE – DEVELOPMENT AND IN VITRO CHARACTERIZATION
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Abstract: The purpose of this study was to develop and characterize novel gel formulations of oleogels and oleo-hydrogels (bigels) as topical drug delivery systems for ketoconazole (KET). Oleogels were prepared using paraffin oil, rapeseed oil or castor oil as a solvent and Aerosil® 200 as organogelator with addition of surfactant Tween 80. Bigels were prepared by mixing castor oil oleogels with sodium alginate hydrogel. The received formulations were analyzed microscopically, for pH, viscosity and the texture profile analysis was also conducted to examine the mechanical parameters. In addition, the in vitro release of KET was evaluated and ex vivo bioadhesive properties of obtained oleogels and bigels on the rat skin model were estimated. It was found that obtained formulations were non-Newtonian systems, showing a shear-thinning behavior and thixotropic properties, with proper textural features such as firmness, compressibility, adhesiveness. Moreover, they were characterized by beneficial bioadhesive properties. Prepared oleogels and bigels were considered as better formulations in terms of drug release compared to commercially available ketoconazole cream.
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