Journal
Article title
Authors
Content
Full texts:
Title variants
Languages of publication
Abstracts
A series of substituted amides of isocyclic and heterocyclic acids have been synthesized. All obtained compounds were evaluated qualitatively for their anticonvulsant activity in the maximal electroshock seizure test (MES test) and psychomotor seizure test (6 Hz test) in mice after intraperitoneal administration. The neurological toxicity was determined in the rotorod neurotoxicity test (Tox test). Two of these compounds appeared most promising: 3-oxo-1-cyklopentanecarboxylic acid 2-fluorobenzylamide (5), 1-cyclopentenecarboxylic acid 2-(trifluoromethyl)benzylamide (8) and were tested quantitatively in MES test in mice after oral administration (o.p.) and in 6 Hz test in mice after intraperitoneal administration(i.p.). Compound (5) showed MES ED50 =82.65 mg/kg and compound (8) showed 6 Hz ED50=84.13 mg/kg.
Year
Volume
Issue
Physical description
Dates
published
2018-06-30
Contributors
author
author
author
author
author
author
References
Document Type
Publication order reference
Identifiers
YADDA identifier
bwmeta1.element.ceon.journal-50ad9b50-0102-35a7-9a4a-1a38675201ed-year-2018-volume-75-issue-3-article-75594