PL EN


Preferences help
enabled [disable] Abstract
Number of results
2018 | 75 | 3 |
Article title

Synthesis and study of substituted amides of some 5-membered isocyclic and heterocyclic acids as potential anticonvulsants

Content
Title variants
Languages of publication
EN
Abstracts
EN
A series of substituted amides of isocyclic and heterocyclic acids have been synthesized. All obtained compounds were evaluated qualitatively for their anticonvulsant activity in the maximal electroshock seizure test (MES test) and psychomotor seizure test (6 Hz test) in mice after intraperitoneal administration. The neurological toxicity was determined in the rotorod neurotoxicity test (Tox test). Two of these compounds appeared most promising: 3-oxo-1-cyklopentanecarboxylic acid 2-fluorobenzylamide (5), 1-cyclopentenecarboxylic acid 2-(trifluoromethyl)benzylamide (8) and were tested quantitatively in MES test in mice after oral administration (o.p.) and in 6 Hz test in mice after intraperitoneal administration(i.p.). Compound (5) showed MES ED50 =82.65 mg/kg and compound (8) showed 6 Hz ED50=84.13 mg/kg.
Year
Volume
75
Issue
3
Physical description
Dates
published
2018-06-30
References
Document Type
Publication order reference
Identifiers
YADDA identifier
bwmeta1.element.ceon.journal-50ad9b50-0102-35a7-9a4a-1a38675201ed-year-2018-volume-75-issue-3-article-75594
JavaScript is turned off in your web browser. Turn it on to take full advantage of this site, then refresh the page.