Protection and regeneration of esophageal, pharyngeal, and laryngeal mucosa as a major element in therapy of patients with esophageal and extraesophageal reflux symptoms

• Authors: Anita Gąsiorowska

Abstracts

EN

Treatment of esophageal and extraesophageal reflux syndromes is mainly focused on inhibiting the secretion of hydrochloric acid. In spite of the high efficacy of proton pump inhibitors, approx. 30–60% of GERD patients experience daily symptoms. Beside acid reflux, other factors such as abnormal esophageal peristalsis, visceral hypersensitivity, ineffective esophageal clearance mechanisms, and impaired mucosal barrier also play an important role in generating GERD symptoms. An additional therapeutic proposition is a procedure aimed at improving the defense mechanisms of esophageal mucosa rather than inhibiting the damage-inducing factors. The preparation consisting of hyaluronic acid (HA), chondroitin sulfate (SC) and poloxamer 407 protects against harmful factors (hydrochloric acid, pepsin) and accelerates mucosal healing and regeneration, constituting a substantial element of monotherapy or add-on therapy in patients with gastroesophageal reflux disease.

Keywords

EN

gastroesophageal reflux disease; hyaluronic acid (HA) plus chondroitin sulphate (CS) and poloxamer 407; laryngopharyngeal reflux

• Journal: Otolaryngologia Polska
• Year: 2020
• Volume: 74(4)
• Pages: 40-45

Dates

published

2020-08-21

Contributors

author

Anita Gąsiorowska

Identifiers

DOI

10.5604/01.3001.0014.3614